Job Description

We are currently seeking an established leader and drug hunter for the R&D (Research & Development) Chemistry group. In this position, they will play a key role in expanding the Regeneron small molecule and peptidomimetic antibody-conjugate drug discovery capabilities, while providing innovation and leadership to seamlessly combine with the company’s existing expertise in biologics and novel genetic medicines. The candidate will drive the discovery of multi-modality antibody conjugate drug therapeutics containing diverse payload possibilities (e.g., small molecules – cytotoxic and non-cytotoxic, targeted protein degraders, peptidomimetics, receptor agonists, etc.) across research areas such as oncology, metabolic disease, infectious disease, immunology and inflammation, neuroscience, and ophthalmology. Cultural fit with the Regeneron cross-functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative environment with other technology, biology and therapeutic area groups. Successful candidates will have a synthetic organic/medicinal chemistry background and will require small molecule and peptidomimetic discovery and SAR (structure-activity relationship) optimization expertise as well as antibody linker-payload synthesis experience. A firm understanding and grasp of chemical biology strategies and the importance of applying both chemical and biological solutions to solve problems in drug discovery will be key. Significant knowledge in the latest and most advanced bioconjugation techniques, platforms, and strategies is desired. We expect they will act as an inspiring and motivating leader, effective communicator, and strong collaborator to lead and drive project teams to develop novel antibody-targeted drug therapeutics and to address challenges related to synthesis, medicinal chemistry, bioconjugation and optimal in vitro and in vivo properties leading to development candidates.

A day in the life of a Director – R&D Chemistry may look like:

• Directly supervise and manage the day-to-day activities of the R&D Chemistry group, providing vision, inspiration, and both short-term and long-term goals. Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group.
• Perform medicinal chemistry SAR-driven optimization of novel small molecule and peptidomimetic drug modalities to provide overall optimal in vitro and in vivo properties of the antibody-targeted therapeutics
• Champion and lead the R&D chemistry efforts on multiple internal/external project teams, and demonstrate the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron development candidates
• Identify new strategies and technologies and improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of small molecule and peptidomimetic drug modalities
• Set priorities, accelerate, and ensure successful progression of the group’s technology and pipeline projects.
• Actively participate in departmental, cross-functional, senior leadership, and external meetings to contribute expertise and to represent the goals and vision of the R&D Chemistry group.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.
• Challenge and mentor the R&D Chemistry group to provide opportunities, visibility, and development for all group members.

This might be the right role for you if:

• You are passionate and enthusiastic about the promise of small molecule conjugated, antibody-targeted therapeutics and appreciate the challenges and opportunities of drug delivery and molecular targeting.
• You enjoy applying and combining traditional methods and novel technologies to develop solutions for synthesis, bioconjugation and drug discovery.
• You are comfortable working in a cross-functional role and excel as part of a diverse team where egos are checked at the door.
• You want to provide meaningful contributions to the development of an organizational culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline.
• You prefer to work in an organization that is modality agnostic, letting the data determine the best course forward.

In order to be considered qualified for the role, you must:

Have a Ph.D. in synthetic organic chemistry (or related), extensive drug discovery experience with antibody-targeted small molecule and peptidomimetic drug modalities including their synthesis and manufacturing, and expertise in modern methods in medicinal chemistry structure-activity relationships. Additional relevant experience should include a deep understanding of biological MOAs, extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, tox evaluation, and a minimum of 10 years of industry experience. A track record of success in the field of small molecules, peptidomimetics, or antibody targeted therapeutics (i.e., advancement of molecules into the clinic), with experience building and leading teams is required. Working collaboratively with both internal and external organizations (e.g., CROs) is essential.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

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